Somayeh Rahmani1, Hamed Mortazavi1, Solmaz Mohamadkhani2, Nima Aminzadeh2* and Mahshid Namdari3
Background: Oral Lichen Planus (OLP) is a chronic autoimmune, inflammatory disease. Previous studies have shown the association of this disease with changes in several blood parameters. This study aimed to conduct a comprehensive study and determine the status of blood parameters of OLP patients that previous studies had shown conflicting evidence of changes. Materials and Methods: In this cross-sectional study, 59 patients with OLP (case group) were compared with 60 healthy individuals (control group). Subjects’ blood profile was analyzed for Hemoglobin, Serum Iron, FBS, HDL, LDL, Cholesterol, Triglyceride, T3, T4, TSH, blood group and RH antigen. Blood indices of case and control groups were compared in regard to age, gender, and Body Mass Index (BMI). Data were analyzed by using Independent T-test, Pearson Chi-square, Linear Regression, and Logistic Regression. Results: The mean values of LDL, Cholesterol, Triglyceride, TSH and FBS were significantly higher in the case group (P<0.05) and the mean values of T3 and T4 were significantly lower in the case group compared to the control group. Frequency of Rh+ factor was significantly higher in the case group. Considering gender, in the case group, the mean values of serum Iron, hemoglobin and T3 indices was significantly lower in women and TSH values were significantly higher in women. There was a significant difference between subjects with normal and above normal BMI in Serum Iron, Cholesterol and Triglyceride indices (P<0.05). Conclusion: Blood profile of people with OLP, in most of the studied indices was significantly different from healthy people.