The association of HLA-A, -B gene polymorphisms with acute l | 3314

Jornal de biologia e mundo de hoje

ISSN - 2322-3308


The association of HLA-A, -B gene polymorphisms with acute lymphoblastic leukemia (ALL) in Iranian patients

"Maryam Mehdizadeh, Mohammad Taghi Akbari, Arezou Sayad, Reza Haji Hoseini, Mahshid Mehdizadeh, Mahdi Tabarraei, Manouchehr Keihani, Yasaman Mohseni, Elham Roshandel, Soheila Abedinpour, Abbas hajifathali

"Leukemia was the first disease in which the involvement of the major histocompatibility complex (MHC) was reported. MHC is a polygenic and polymorphic system containing the loci for genes coding class I, II and III of HLA (Human Leukocyte Antigen) genes which are one of the most polymorphic loci in the human genome, located on the short arm of chromosome 6 (6p23). In the present study, the relation between HLA-A,-B various alleles and ALL disease was investigated in Iranian patients. Eleven ALL cases who referred to bone marrow transplantation department of Taleghani Hospital and fifty healthy controls were randomly selected. DNA extraction was performed by salting out method followed by HLA-A, -B typing based on PCR-SSP technique using HLA-READY GENE of Inno-Train kits. DNA analysis demonstrated that the frequency of HLAA* 11 (pc= 0.009; OR: 9.510; 95% CI: 2.077- 43.537) was significantly higher in ALL patients than controls. According to these results, the HLA –A alleles may lead to susceptibility to ALL in Iranian patients. The results suggest that there is contribution between HLA-A*11 gene and ALL developing in Iranian patients. But, large sample size should be study to achieve more reliable outcomes."