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Antibodies with Functionality as a New Generation of Transla | 56495

Jornal de Ciências Farmacêuticas e Desenvolvimento de Medicamentos

Abstrato

Antibodies with Functionality as a New Generation of Translational Tools designed to be programmed via translational resources to predict and to prevent Demyelination

Sergey Suchkov

Abs against myelin basic protein/MBP endowing with proteolytic
activity (Ab-proteases with functionality) are of great value
to monitor demyelination to illustrate the evolution of multiple
sclerosis (MS). Anti-MBP autoAbs from MS patients and
mice with EAE exhibited specific proteolytic cleavage of MBP
which, in turn, markedly differed between: (i) MS patients and
healthy controls; (ii) different clinical MS courses; (iii) EDSS
scales of demyelination to correlate with the disability of MS
patients to predict the transformation prior to changes of the
clinical course.

Isenção de responsabilidade : Este resumo foi traduzido utilizando ferramentas de inteligência artificial e ainda não foi revisado ou verificado.