Ada Manukyan, Roman Jirák, JiÅà Raboch, ZdenÄk FiÅ¡ar, Martina ZvÄÅová and Pavel Martásek
Objectives: The aim of this study was to find out how some of the genetic polymorphisms influence the clinical picture of the dementia syndrome, in other words how some clinical features correlate with certain genetic abnormalities.
Methods: Altogether 183 people were examined; they were either ambulatory patients of the Psychiatric clinic or people of corresponding age. Patients that suffered with Alzheimer’s disease numbered 86, healthy control subjects numbered 97. A single blood sample was collected from each of the test subjects in order to be used for genetic testing.
Results: The statistical analysis of the data about the influence of individual polymorphisms on the development of depression, behavioral disorders and delirium at the group of patients with Alzheimer’s disease was made. The acquired results provide the possibility to assume that the presence of the G/G polymorphism in neurotropic factor of the brain and the A/G in 5-HT2A-receptors can manifest as a protective factor of delirium incidence among the patients with AD. The carriers of the aforementioned polymorphisms of the examined group of patients the deliriums weren’t present among 70.21% and in 69.05% of the cases.
Conclusion: Our study was of a pilot character. The most important of our result was the finding of higher number of polymorphisms G/G for BDNF and A/G for 5-HT2A serotoninergic receptors among patients, that didn’t suffer from deliriums. A follow up research will focus on this findings. The study was supported by a grant Progress Q27.